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ST. LOUIS (AP) — Rep. Todd Akin renewed his vow to carry on with his embattled Senate campaign Tuesday, even as a key deadline loomed to withdraw from the race over his comments that women's bodies can prevent pregnancies in cases of "legitimate rape."

Akin, who has been frantically trying to salvage his once-promising bid against incumbent Democrat Claire McCaskill, insisted the uproar surrounding his remarks was an overreaction to misspeaking "one word in one sentence on one day."

For the second time in two days, Akin went on the radio show hosted by former Republican presidential candidate Mike Huckabee to say he planned to stay in the race, despite constant urging from prominent members of his own party to step aside.

"I guess my question is: Is there a matter of some justice here?" Akin asked. After his original statement, "all of a sudden, overnight, everybody decides, 'Well, Akin can't possibly win.' Well, I don't agree with that."

The race has long been targeted by the GOP as crucial to regaining control of the Senate.

"I hadn't done anything morally or ethically wrong, as sometimes people in politics do," Akin said. "We do a lot of talking, and to get a word in the wrong place, still, that's not a good thing to do, or to hurt anybody that way, it does seem like a little bit of an overreaction."

Hours earlier, he posted a video online in which he apologized again.

But ominous signs were mounting against the six-term legislator from suburban St. Louis, most notably the apparent loss of millions of dollars in campaign advertising money.

The decision to stay or go has some urgency. Missouri election law allows candidates to withdraw 11 weeks before Election Day. That means the deadline to exit the Nov. 6 election is 5 p.m. Tuesday. Otherwise, a court order would be needed to remove a name from the ballot.

The uproar began Sunday, when St. Louis television station KTVI aired an interview in which Akin was asked if he would support abortions for women who have been raped.

"It seems to me, first of all, from what I understand from doctors, that's really rare. If it's a legitimate rape, the female body has ways to try to shut that whole thing down," Akin said.

The comments drew a sharp rebuke from fellow Republicans, including presumptive presidential nominee Mitt Romney and his vice presidential choice, Rep. Paul Ryan, of Wisconsin.

The Senate's top Republican, Mitch McConnell, said Tuesday that Akin "made a deeply offensive error at a time when his candidacy carries great consequence for the future of our country." McConnell said the apology was insufficient.

A day after nudging Akin by suggesting he "take time with his family" to consider his future, McConnell said it was time for Akin to drop out.

North Carolina Sen. Richard Burr and New Hampshire Sen. Kelly Ayotte joined McConnell, as did five patriarchs of the Missouri Republican Party.

Sen. Roy Blunt and four former senators from Missouri — John Ashcroft, Kit Bond, Jim Talent and John Danforth — issued a joint statement saying they "do not believe it serves the national interest" for Akin to remain in the race.

After his defiant statements on Huckabee's show, Senate Republicans' campaign arm reiterated that it would not support Akin's campaign.

"The stakes in this election are far bigger than any one individual," said Brian Walsh, a spokesman for the National Republican Senatorial Campaign Committee. By staying in the race, Akin "is putting at great risk many of the issues that he and others in the Republican Party are fighting for."

The committee had set aside $5 million for advertising and had other plans for logistical and field support for Akin's campaign before his comments on Sunday.

At least one outside group that has advertised extensively in Missouri, the Karl Rove-backed Crossroads GPS, has also said it was also pulling all of its advertising in Missouri.

Two GOP officials, speaking on the condition of anonymity because they did not want to irritate Akin, said party officials seeking to talk with him were having trouble reaching him Monday night and Tuesday morning.

Akin campaign spokesman Ryan Hite declined Tuesday to reveal Akin's whereabouts but said he was not in his suburban St. Louis campaign office. Hite said the campaign may release information about his public schedule later.

The apology video Akin posted on YouTube early Tuesday was an apparent attempt to claw back some of the lost funding.

"Fact is, rape can lead to pregnancy. The truth is rape has many victims. The mistake I made was in the words I said, not in the heart I hold. I ask for your forgiveness," he said in the video.

Just two weeks ago, Akin was at the top of the political world in Missouri after winning a hotly contested three-way battle with millionaire businessman John Brunner and former state Treasurer Sarah Steelman for the right to challenge McCaskill in the November election. Missouri has grown increasingly conservative in recent years, and McCaskill is seen as vulnerable.

One anti-abortion group expressed support for Akin, while another called on him to step aside.

Missouri Right to Life, which opposes a woman's right to get an abortion even in cases of rape and incest, said Akin's "consistent defense of innocent unborn human life clearly contrasts" with McCaskill's position. But the Christian Defense Coalition called on him to withdraw.

Names are being floated about a possible replacement for Akin. A favorite is Tom Schweich, the state auditor who was courted to run for Senate earlier this year but declined.

Other names mentioned include former Gov. Matt Blunt, the son of Sen. Roy Blunt; two members of Missouri's House delegation, Blaine Luetkemeyer and Jo Ann Emerson; and Akin's two unsuccessful primary opponents, Brunner and Steelman.

Talent, who lost his seat to McCaskill in 2006, said Monday he had been asked to run but declined.

If Akin were to leave, state law gives the Republican state committee two weeks to name a replacement. The new candidate must file within 28 days of Akin's exit.

Associated Press writers Henry C. Jackson in Washington; Jim Suhr in St. Louis; and Chris Blank and David Lieb in Jefferson City, Mo., contributed to this report.

WASHINGTON (AP) — Republican presidential candidate Mitt Romney is reshaping his message from an all-economic pitch to an all-out challenge to what he argues is a failed status quo, taking a risk with barely 50 days to go in the campaign.

Former Republican National Committee Chairman Ed Gillespie will have an elevated role in shaping the campaign message for the GOP nominee and will focus it more tightly on a broader change-versus-status-quo strategy.

"The timing is right at this moment to reinforce the specifics, more specifics about the Romney plan for a stronger middle class," Gillespie told reporters during a conference call Monday.

The point, Romney aides said, is that if voters find all aspects of the status quo, including economic and foreign policy, acceptable, they should vote to re-elect President Barack Obama. But if they are fed up with what Romney argues is failure across the board by Obama, they will turn to Romney.

With the campaign momentum currently on Obama's side, Romney sought Monday to explain to voters more clearly what he would do as president, as he looked to right his struggling campaign and ease worries in Republican circles about its state seven weeks before Election Day.

As the outward strategy changes, the Romney campaign also has launched a quiet outreach effort designed to stem dissention among the Washington Republicans who have been more and more vocal in their criticism of the nominee's campaign.

Key Romney aides have been tasked with leading the effort, which also includes discussions with Washington consultants tied to outside groups that have poured tens of millions of dollars into the presidential contest so far. Those groups, which are keenly aware of the perceived problems inside Romney's camp, are weighing how to balance limited resources between the presidential campaign and congressional races in the coming weeks.

Romney was using his own campaign dollars to launch new television ads highlighting his plans as he prepared to address a Hispanic business group in Los Angeles.

"My plan is to help the middle class," the Republican nominee says in a new TV ad in which he promises to cut the deficit, balance the budget, reduce spending and help small business. "We'll add 12 million new jobs in four years."

It was one of two new commercials he was launching in the most competitive states — the other assails Obama as bad for middle-class families — while also re-focusing his campaign appearances on his previously released five-point economic plan and starting a new effort to try to narrow Obama's advantage with Hispanic voters.

In addition, Romney was preparing to make a series of speeches aimed at offering voters a more concrete outline of his plans for the country and he's spending a significant amount of time preparing for next months' series of debates, mindful that the face-to-face meetings may be his last best hope of overtaking Obama.

The emphasis on Romney's plans for the future comes after a week in which Republican veterans of presidential campaigns publicly implored the GOP nominee to give voters a clearer sense of how he would govern, saying that simply castigating Obama wouldn't be enough to win. The new effort also follows a series of polls that show Obama with an edge nationally and in key states, and amid reports of infighting at Romney's Boston-based campaign.

With griping in GOP circles mounting, Romney and his advisers spent the weekend in Boston hashing out a plan to try to shift the dynamics of the race before the first debate on Oct. 3.

After a turbulent week that saw Romney stumbling to respond to an ongoing crisis in the Middle East, Romney chose to try to return to his comfort zone — the economy — and his argument that only he can solve stubbornly high unemployment given his decades of work in the private sector.

Wisconsin Rep. Paul Ryan, Romney's running mate, was to emphasize that pitch this week in appearances while also zeroing in on the debt and deficit.

Romney, for his part, was starting the week with a speech Monday to the U.S. Hispanic Chamber of Commerce in Los Angeles, as he looks to narrow Obama's advantage with these Democratic-leaning voters in key battleground states.

The campaign also was working to counter the notion of a campaign in disarray after a Sunday story on the Politico website detailed infighting among Romney's senior staffers. Campaign advisers worked to downplay those tensions and insisted the campaign is still on track.

"Obama's entire foreign policy is in flames. The economy is terrible. Let's get a little distance from the convention," top strategist Stuart Stevens wrote in an email Sunday morning, seeking to counter the notion of a campaign in a downward spiral.

It's been a tough few weeks for Romney.

Trouble began with Clint Eastwood's rambling conversation with a chair on the final night of the Republican convention, right before Romney's keynote address omitted the war in Afghanistan or a thanks to the troops serving there.

The intervening weeks have been scattered. Romney ducked battleground states as he hunkered down in Vermont for debate preparation, then spent days defending his decision to omit war from the speech. Polls showed the Democratic convention gave Obama a boost.

Then violence erupted in Egypt and Libya, prompting Romney to issue a statement criticizing the Obama administration before it was known that an American ambassador had died in Libya. Romney doubled down on his criticism in a news conference the next day.

That drew criticism from both Democrats and Republicans alike.

Romney's team sought last week to try to shift the tide by working harder and spending more on TV. The campaign released a flight of ads for different states during the week of the Democratic convention, but later replaced almost all of them with the same ad attacking Obama's record on China.

That was just last week. The new pair of ads were rolled out Monday.

Romney's campaign is spending more money on the ads now that they have access to funds raised for the general election. Over the summer, Romney also benefited from vast sums spent by independent groups on his behalf. Through last week, American Crossroads and Crossroads GPS spent a combined $107.5 million on presidential election television advertising. That's $20 million more than Romney's campaign over the same time period, according to spending figures obtained by The Associated Press. Romney has also benefited from $46.5 million in television spending by Americans For Prosperity.

The Crossroads groups and Americans For Prosperity have long planned to balance their spending between the presidential contest and House and Senate races. Romney aides fear that the outside spending may now shift disproportionately toward the congressional races.

"We've always planned to spend substantially more on presidential level advocacy, but also spending significantly on House and Senate races," said Jonathan Collegio, spokesman for American Crossroads.

Thomas reported from Los Angeles. Associated Press writers Steve Peoples in Washington and Thomas Beaumont in Des Moines, Iowa, contributed to this report.

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